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For example, deletion of hepatic Hmgcs2 using antisense oligonucleotides resulted in a significant increase in hepatic neutral lipid accumulation following regular chow and high-fat feeding conditions in both neonates and adult mice ( hmgcs2 results in a massive deposition of hepatic triglycerides in neonates ( Srebp1 , Chrebp1 , and Scd2 (Fabbrini et al., 2008

They also demonstrated that dietary supplementation of apoE / mice with choline, TMAO or betaine drives atherosclerosis by upregulating the scavenger receptors CD36 and SR-A1 on macrophages, leading to increased cholesterol accumulation and formation of foam cells (Geng et al., 2018)

In another study, patients with advanced cancer receiving chemotherapy and presenting low levels of serum carnitine were treated with oral l-carnitine (4 g daily for 7 days) [21]
