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Consistent with historical practice, we account for rare situations of non-monotonicity in a base MS-DRG and its severity levels, where the mean cost in the higher severity level is less than the mean cost in the lower severity level, in determining the relative weights for the different severity levels

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Specifically, lactate production by metastatic colorectal cancer cells induces mitochondrial stress, increased ROS, and apoptosis in NK cells (224)

For example, there is evidence for toxin-related PD, which implies that toxins released by infectious agents might also be responsible for some cases of sporadic PD