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It is marked by massive iron-induced lipid oxidation, enhanced oxidative stress, and depletion of antioxidant defenses
T13 exhibited inhibitory activity of d-lactate formation and cytotoxicity in DMS273 cells at comparable concentration ranges (IC 50 = 4.6 M, LC 50 = 1.9 M, Fig

This is due to an impairment in dTMP synthesis which leads to cell cycle arrest in S-phase of rapidly proliferating cells, in particular hematopoietic cells

Exp Neurol 198(2):382390
