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Manganese is a transition metal capable of oscillating between several oxidation states which makes it suitable for the accommodation of superoxide radical anion and the design of SOD mimetic compounds (Vincent et al

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For instance, an investigation conducted at Kursk State Medical University evaluated the effects of GSH levels on an individual's ability to recover from COVID-19 infection and concluded that high ratios of ROS over GSH appeared to be strongly related to symptom severity and extended recovery times [76]

It regulates and controls the basal expression of an array of ARE antioxidant response element-dependent genes to regulate various physiological outcomes of oxidant exposure [9]