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Riboflavin Riboflavin is one of the most essential vitamins B due to its properties, such as anti-inflammatory, antioxidant, anti-nociceptive, and anti-aging (2225)

Nat Rev Immunol 20: 529536 Christ A, Gnther P, Lauterbach MAR, Duewell P, Biswas D, Pelka K, Scholz CJ, Oosting M, Haendler K, Baler K et al (2018) Western diet triggers NLRP3dependent innate immune reprogramming

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Mechanistically, IR and compensatory HI increase the hypothalamic gonadotropin-releasing hormone (GnRH) pulsatile frequency, which causes the pituitary gland to secrete too much LH (Patel et al., 2003)