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Improved PFS was seen when a PD-L1 inhibitor (atezolizumab) was added to the combination of a BRAF plus MEK inhibitor (vemurafenib plus cobimetinib)

Similarly, MSH presented positive results in a model of renal fibrosis, induced by the administration of cyclosporine A, including reduction in TGF-1, inflammatory markers, cell apoptosis and collagen deposition (192)

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