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The COBRRA randomized international trial compared treatment for three months with either apixaban or rivaroxaban in 2,760 adults with acute venous thromboembolism (VTE)

In clinical practice, good response to treatment with parenteral vitamin B12 has been observed

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The authors note consistently positive healing signal across studies but explicitly flag that the bulk of the work has been done in small-rodent models useful for calibrating any extrapolation to larger-animal or human work and for grounding any soft-tissue-research literature review