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To date, there are few studies aimed at evaluating the effects of long-term therapy with cereblon-based PROTACs, the factors affecting therapeutic efficacy, and the emergence of resistance to their use
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P., Grice, G

The atypical 2-Cys Prdxs (Prdx5) are monomers forming intramolecular disulfide since both Cys R and Cys P are within the same molecule