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Description
MenSC-Exos promote M2 polarization by modulating inducible nitric oxide synthase activity and the ARG: inducible nitric oxide synthase ratio, with a sustained increase in the M2/M1 ratio observed between days 714 posttreatment (Dalirfardouei et al., 2019
These trials primarily investigate the antioxidant effect of glutathione in healthy individuals or various diseases
Further studies have shown the absence of GSH in T cells does not interfere with TCR signaling but leads to a failure to reprogram cellular processes needed for robust clonal expansion and prevents the induction of aerobic glycolysis and the increase in cell size associated with T cell activation (Klein Geltink et al., 2017)

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