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To assess fasting-induced c-Fos expression in the ARH, control and AgRP GHR KO mice carrying the Cre-inducible tdTomato-reporter protein ( n = 5/group) were perfused after 24 h of fasting

By 2013, a study had identified the PGC-1/FNDC5/BDNF axis as a crucial bridge linking skeletal muscle metabolism to central neuroplasticity [29], further underscoring exercise and its mimetics as systemic regulators of brain health and opening new therapeutic avenues for neurodegenerative diseases

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