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PPIs lower stomach acid, making it hard to absorb B12

Oral administration of high-dose vitamin B 12 (1 to 2 mg daily) is considered as effective as intramuscular administration for correcting anemia and neurologic symptoms Despite many studies suggesting oral administration of vitamin B 12 to be easy, effective and less costly than intramuscular administration, debate surrounds the effectiveness of the oral route

Vitamin B12 is watersoluble, meaning that excess amounts not needed by the body are usually filtered out through urine

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