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3.3 Dual role of Se deficiency in cretinism Cretinism often occurs in areas where endemic goiter is prevalent, with mucinous edema cretinism being the main manifestation of hypothyroidism without goiter
First, Hcy condenses with serine to form cystathionine in a reaction catalyzed by cystathionine synthase (CBS), which requires vitamin B 6
Clinically, AKI has long been considered a hypercatabolic state, which adversely affects outcomes, including mortality 13,14
