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Description
In HG-induced rat cardiomyocytes (H9C2) and HFD/STZ-induced C57BL/6J mouse models, it was found that mitophagy was impaired under hyperglycemic conditions, and that canagliflozin was able to increase the phosphorylation of AMPK and activate PINK1/Parkin-dependent mitophagy at the same time, which could improve the function of mitochondria and play a certain role in the DCM therapeutic effects [177]

R., Audhya T., Geier M

Herxes are caused by treating the disease with medications and antimicrobials and the sickness that follows is from pathogen die off

doi:10.1021/cn500051h Qiao S, Dennis M, Song X, Vadysirisack DD, Salunke D, Nash Z, Yang Z, Liesa M, Yoshioka J, Matsuzawa S-I, Shirihai OS, Lee RT, Reed JC, Ellisen LW (2015) A REDD1/TXNIP pro-oxidant complex regulates ATG4B activity to control stress-induced autophagy and sustain exercise capacity
