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Upon assembly, the inflammasome activates caspase-1, which cleaves gasdermin D (GSDMD) and promotes the maturation and release of pro-inflammatory cytokines such as interleukin-1 (IL-1) and IL-18 ( Figure 2A ) (61)
The gut is also integral to mood regulation, as it produces over 90% of the bodys serotonin, a neurotransmitter essential for emotional well-being
W.SchwarczR
Intrinsic and integrative properties of substantia nigra pars reticulata neurons
