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Guo Z, Ran Q, Roberts LJ 2nd, Zhou L, Richardson A, Sharan C, Wu D, Yang H

Abstract Introduction: Trimethylaminuria (TMAU), also known as fish-odor syndrome, is a rare metabolic disorder characterized by a body malodor that smells like a decaying fish

In past decades, analytical methods such as liquid chromatography-mass spectrometry (LC-MS) 15 , enzyme-linked immunosorbent assay (ELISA) 16 , gas chromatography-mass spectrometry (GC-MS) 17 , surface-enhanced raman scattering (SERS) 18 and polymer monolith microextraction combined with electrospray ionization quadrupole time-of-flight mass spectrometry (PMEM/ESI-Q-TOF-MS) 19 have been developed for the analysis of trace -agonists residues in various food matrices

However, elevated concentrations of these metabolites have been associated with higher risk of obesity 11 , type 2 diabetes 12,13 and cardiovascular disease 14