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This side effect is more commonly observed in beginners or those who take higher initial doses

MS-R, AD, LP, MI, NM, MM, WS, DC, WC, and JS-R contributed to the review and editing
[DOI] [PubMed] [Google Scholar] 3.Habtezion A., Gukovskaya A

For the participants who finished phase 2, there was little change in severity of diarrhea (0.52 +/-0.79 at beginning, 0.57 +/- 0.79 at end) and a small increase in severity of constipation (0.61 +/- 0.89 to 0.87 +/- 1.1, not significant)
