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On the basis of the available evidence, the areas of strongest research supporting the use of treatments inclusive of B12 are post-herpetic neuralgia, alcohol-related neuropathy and diabetic neuropathy, but these areas along with pain caused by peripheral neuropathy of other causes, require further exploration

Adding a phosphate binder should be the last step , as it can cause constipation, which causes discomfort, and you want this binder to be a last resort or have something to go to when their CKD worsens and the Stage of CKD rises

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The radiology facility or your own doctor will give you specific instructions about whether you need to stop or reduce the medication and when to restart the medication