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The first effects appear progressively : Weeks 1-2 : better energy during training, reduced post-workout fatigue sensation Weeks 2-4 : improved recovery, first measurements on waist circumference for weight loss profiles Weeks 4-8 : measurable improvement in endurance, more visible fat loss Weeks 8-12 : full effects in terms of body composition and performance L-carnitine saturation of muscle levels takes several weeks because intramuscular concentration increases slowly

This isn't physiological damageit's the normal receptor adaptation process, and appetite typically normalizes within 710 days

doi: 10.1016/S0304-3940(97)13476-0

BMC Cancer 12(16):629