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According to the Centers for Medicare & Medicaid Services (CMS), Original Medicare (Parts A and B) covers vitamin B12 injections when theyre medically necessary when: You have a history of low blood levels of vitamin B12 or conditions that are caused by or cause low B12 levels such as certain autoimmune and gastrointestinal disorders

-polycythemia vera -In patients with History of bronchospasm, asthma, allergic rhinitis or urticaria in relation to previous treatment with NSAIDS

Side Effect 5: Systemic Effects Systemic reactions may include fatigue, anxiety, and numbness in extremities