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doi: 10.1016/j.clinbiochem.2003.09.010
Catechins are the major powerful and pharmacologically active compounds in tea
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Since both the hydroxylation action from PHDs and ARD-1 expression require the presence of oxygen, under hypoxic condition, neither hydroxylation nor acetylation of HIF-1 proline and lysine residues occurs, resulting in stabilization of HIF-1 structure
