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Most available studies are preclinical or conducted on small human samples, which limits the ability to conclusively state their long-term efficacy and safety

Cycling protocols: While most studies use continuous daily dosing, some researchers explore cycling protocols (e.g., 5 days on, 2 days off) to potentially prevent tolerance or reduce injection frequency

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Early improvements may include reduced discomfort and better digestion, while deeper structural repair develops over several weeks of consistent use