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Summaries of results of carcinogenicity studies on 1,2-dibromoethane Study Route Animal Statistically significant effects dose (numbers of animals with effects/total numbers of animals) NCI (1978) gavage mouse squamous cell carcinoma of the forestomach control (M: 0/20, F: 0/20), 62 mg/kg (M: 45/50, F: 46/49) 107 mg/kg (M: 29/49, F: 28/50) alveolar/bronchiolar adenoma control (M: 0/20, F: 0/20), 62 mg/kg (M: 4/45, F: 11/43) 107 mg/kg (M: 10/47, F: 6/46) rat squamous cell carcinoma of the forestomach control (M: 0/20, F: 0/20), 38 mg/kg (M: 45/50), 37 mg/kg (F: 40/50) 41 mg/kg (M: 33/50), 39 mg/kg (F: 29/50) hepatocellular carcinoma control (M: 0/20, F: 0/20), 39 mg/kg (F: 6/48) haemangiosarcoma control (M: 0/20, F: 0/20), 38 mg/kg (M: 11/50), 41 mg/kg (M: 4/50) Van Duuren et al