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There is no direct evidence to suggest that MTHFR mutations significantly reduce life expectancy unless in the case of triple and quadruple mutation combinations

Shift life: 24 months

Of course, you shouldn't be making medical decisions based on a blog post like this one

Gut-brain axis (GBA) is a bidirectional communication network between the gastrointestinal tract (GIT) and CNS, involving nervous, immune, and endocrine systems (13)
