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A deficiency can lead to a type of anemia that causes pale skin and shortness of breath

Notably, several of the pro-inflammatory cytokines known to upregulate CD38 expression, including IL-6, interferons, TGF-, as well as SASP, are also implicated in SSc 2
The serum B12 level serves as the initial screening test, with values below 148 pmol/L generally indicating deficiency, and levels between 148221 pmol/L considered borderline