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Nitrates, including GTN, can inhibit ALDH2 activity (139,140)
Vatalanib sensitizes ABCB1 and ABCG2-overexpressing multidrug resistant colon cancer cells to chemotherapy under hypoxia
Despite compelling preclinical evidence, clinical translation of Nrf2 activators for MIRI remains in its infancy, with a significant lack of published trial data specifically in this acute setting (summarized in Table 1)
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