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The dose of the drug was adjusted weekly throughout the study period based on changes in the weight of the mice

Degenerative pathways would dominate, promoting cell death upon neurotrophin binding to p75 NTR through activation of pro-apoptotic JNK-p53-Bax pathway or suppressing Ras/PI3K/Akt activation when conditions of either lacking or deficient Trk signaling or increased p75 NTR expression occur 6

Dosing hasnt been standardized, long-term effects arent fully known, and product quality can differ between sources