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The research team also utilized epigenomic data (such as assay for transposase-accessible chromatin by sequencing (ATAC-seq)) to explore drug-induced changes in chromatin accessibility (Zou et al., 2021), discovering that epigenetic regulatory factors (such as Histone Deacetylases) may become synergistic targets to enhance drug sensitivity (Ramaiah et al., 2021)

and (d) phosphoenolpyruvate to pyruvate

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To reduce or prevent free radical-directed oxidative damage, the human body has developed an antioxidant defence mechanism that involves free radical scavenging, metal chelating, and enzymatic activities to neutralize the reactive species just after they have formed