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For instance, quercetin-3-glucoside from apples and onions reduces oxidative stress similar to metformin, while epigallocatechin-3-O-gallate (EGCG) found in green tea increases energy expenditure and decreases inflammation and oxidative stress by inhibiting the NF-kB pathway [68]

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This need challenges us to understand how a precursor cell gives rise to the pancreas and to characterize the gene products that specify cell fates during organogenesis
