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Bae I, Fan S, Meng Q, et al

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Although these direct antioxidant effects are observable in vitro, their significance in vivo appears limited, stemming from low plasma concentrations of NAC and the prevalence of more abundant endogenous antioxidants such as GSH, ascorbate, and antioxidant enzymes (e.g., SODs, GPs, CAT) [6,38,39]

Additionally, elesclomol enhanced the cytotoxicity of TH588, a microtubule-modulating agent that induces cell cycle arrest, which relies on endogenous ROS levels [66]