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In contrast, no difference in glutathione levels was observed in heart or liver between homozygous and WT mice ( S3A and S3B Fig ), consistent with low expression of Chac1 in these tissues

These findings support the understanding that increased ROS in mitochondria may contribute to the etiology of a wide variety of diseases [223-226]

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Abstract Current methods of culturing human epithelial organoids from adult stem cells may not be compatible with clinical applications as they rely on xenogeneic, chemically undefined or non-standardized components such as the basement membrane extract Matrigel