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Molecular mechanisms, current management and next generation therapy in myeloma bone disease

B12 Deficiency Can Affect Nerves B12 deficiency can manifest itself in the nerves

### Regulatory Status and Availability **AOD-9604:** - Never received FDA approval for any indication - Classified by the FDA as a **Category 2 bulk drug substance** not eligible for compounding under Section 503B - Removed from many international peptide supplier platforms (including Alibaba and related marketplaces) - Legal status varies by country

The finding of low plasma sulfate is also consistent with a large study that found high sulfate in the urine of children with autism [41], as sulfate wasting in the urine partly explains low levels in the plasma