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[PubMed] [Google Scholar] Leo MA, Lieber CS

GSH-Grx belongs to the Trx protein family and facilitates the reduction of disulfide bonds to maintain redox homeostasis

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This excess glucosamine gets incorporated onto the serine and threonine residues of transcription factors such as Sp1 resulting in pathologic changes in gene expression of fibrinogen activator inhibitor-1 and transforming growth factor- ( Oxidative stress In the Banting lecture Brownlee referred to overproduction of superoxide (O2 - ) by the mitochondrial electron transport chain as the one element linking the different pathogenic pathways to diabetic complications ( Oxidative stress occurs is a result of an inability of cellular antioxidant mechanisms to neutralize increased generation of reactive oxygen species (ROS) ( 2 - , hydroxyl radical (OH - ), hydrogen peroxide (H 2 O 2 ), and peroxynitrite (ONOO - ) ( 2 - , the most biologically active form of ROS, is created via multiple sources including the electron transport chain, and various enzymes: NADH oxidase, NAD(P)H oxidase, lipoxygenase, cyclooxygenase, xanthine oxidase, cytochrome P-450, and, during periods of tetrahydrobiopterin deficiency, by nitric oxide synthase ( 2 - can react with superoxide dismutase (SOD) acquiring an electron it is converted to H 2 O 2
