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Increased cognitive sensitivity to scopolamine with age and a perspective on the scopolamine model

As ROS production increases, antioxidant defense begins to fail, leading to the accumulation of lipid peroxides [188, 189]

doi: 10.1017/S1461145707008401 6 HalliwellB

In vitro , Sch B suppresses erastin-induced ferroptosis in SH-SY5Y neuroblastoma cells by modulating the GSK3/Nrf2/GPX4 signaling pathway ( in vivo stability, and limited blood-brain barrier permeability ( 2.3 Lipid peroxide accumulation Polyunsaturated fatty acids (PUFAs), which are major constituents of organelle membrane phospholipids, are particularly prone to peroxidation during ferroptosis ( 2+ -driven Fenton reactions, which induce spontaneous oxidation of PUFA-PLs and further accumulation of PUFA-PL-OOHs ( 2+ , ACSL4, MDA, 4-HNE, and -Syn were markedly elevated