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These effects include loss of bone density, endothelial and immune dysfunction, sarcopenia, and systemic cellular stress induced by environmental factors such as microgravity, atmospheric conditions, radiation exposure and mental and physical stress

What the generic summaries miss is the architecture of mechanism the specific receptor interactions, the molecular signaling cascades, the crosstalk between nitric oxide pathways and angiogenic growth factors that explains why a fifteen-amino-acid fragment produces effects observed across tissues as different as gastric mucosa, tendon, skeletal muscle, and peripheral nerve

iNOS is not a secreted protein and was not evaluated for secretion

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