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10.1227/NEU.0000000000000341 Neurosurgery Summary Keywords traumatic brain injury (TBI), chronic traumatic encephalopathy (CTE), animal models of TBI, stress, neuroinflammation, calcium dysregulation, tauopathy Citation Fesharaki-Zadeh A and Datta D (2024) An overview of preclinical models of traumatic brain injury (TBI): relevance to pathophysiological mechanisms

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After an initial loading phase of six injections over two weeks (or more frequently if neurological symptoms are present), maintenance injections are given every two to three months for life to prevent deficiency recurrence