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Hypoxanthine, an important metabolite of purine metabolism, has been reported to cause vascular damage and disruption of the bloodbrain barrier (BBB) in stroke by regulating intracellular Ca 2+ overload and inducing GSDME-dependent endothelial cell pyroptosis [211]

By integrating dietary strategies, evidence-based nutritional support, and pharmaceutical therapeutics one can develop a comprehensive program to help manage inflammatory bowel disease during both disease flares and periods of remission

It was first identified in pathogenic Neisseria species but its homologs have now been found in several medically significant human pathogens, including H