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[DOI] [PMC free article] [PubMed] [Google Scholar] 102.Reddy P., Leong J., Jialal I

Mice that lack an organised synovial lining layer due to the deficiency of cadherin-11 are indeed resistant to the development of arthritis, demonstrating a causal role of fibroblasts in the disease ( + THY1 + cells are mainly mediators of inflammation, the destruction of joint tissues is mostly mediated by FAP + THY1 - fibroblasts ( The driving role of fibroblasts in cancer is also well studied

Microbial metabolic pathways guide response to immune checkpoint blockade therapy