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Some data, however, suggest that the role of NHR-49 in immunity can be uncoupled from its role in longevity, as gene expression and tissue specific rescue of NHR-49 yield different outcomes in innate immunity and longevity (Naim et al., 2021)

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Formally known as Melanotan II, this synthetic cyclic heptapeptide is one of the most widely studied non-selective melanocortin agonists in preclinical science, and its multi-receptor engagement profile makes it a uniquely powerful tool for researchers investigating the broader melanocortin signalling system, rather than any single receptor subtype in isolation