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Alberts JF, et al

As a negative control, the forearm blood flow was measured in response to sodium nitroprusside, an endothelium independent vasodilator, which showed no change compared to baseline after Pycnogenol or placebo intake
Taken together, our data indicate that the PPP is dynamically regulated in growth plate chondrocytes during bone development

Additionally, polysaccharides from Ganoderma lucidum inhibit the protein kinase A and mitogen-activated protein kinase signaling pathways
