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In summary, since EUK series appear to be unique, in that they can scavenge both O 2 and H 2 O 2 , they may be potentially more effective in conditions where the levels of both types of ROS are elevated (e.g., neurodegenerative diseases and ischemic injuries)

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Interestingly, CBS is upregulated by transcription factors such as nuclear factor erythroid 2-related factor 2 (NRF2) 17 , SP1/3 18 , and NFY 18 and its upregulation confers resistance against ferroptosis in ovarian cancer cells 17

Patients with hypothyroidism exhibited, among other things, greater QT interval dispersion, reduced heart rate variability, and abnormalities during the diastolic phase [2]