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DOI: Figure 6figure supplement 1

may improve only after treating underlying inflammation or CKD -Soluble transferrin receptor (sTfR): Normal -CRP/ESR: Raised Iron Deficiency Anemia (IDA): - Low serum iron - High TIBC - Low ferritin - Low transferrin saturation - Microcytic, hypochromic RBCs - Reticulocyte count: Low rapid increase after iron supplementation (marrow responds promptly) - Soluble transferrin receptor (sTfR): Elevated - CRP/ESR: Usually normal Key Investigational Points High ferritin + low TIBC hallmark of ACD

as a result, oxidative stress may promote platelet hyperactivity by reducing the level of physiologically accessible nitric oxide

Recording of electroretinograms (ERGs) in mice and rats Scotopic and photopic ERGs were recorded using an Espion ERG machine (Diagnosys LLC, Littleton, MA) as previously described [9]