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The treatment of tap water creates disinfection byproducts that can affect the levels of minerals like calcium and magnesium in the water

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Triptolide attenuates IL-6-induced activation of STAT3 target genes, such as Mcl-1 and Bcl-2 , by decreasing STAT3 phosphorylation and inhibiting its nuclear translocation in NSCLC (PC9 and A549) cells, while also reversing IL-4 or LPS-induced up-regulation of IL-6 at the gene level, thereby reducing cell survival, apoptosis, and the polarization of myeloid cells into immunosuppressive macrophages and MDSCs within the tumor microenvironment [978, 979]