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As cited above, a key manifestation of oxidative damage to oocytes in endometriosis is comprised by aberrations in the organization of oocyte meiotic spindles and chromosomes, a key morphologic marker for ROS damage and a widely regarded harbinger of impending oocyte and fetal aneuploidy (62, 84, 85)

If these toxic byproducts build up, they can halt energy production entirely

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However, the prevalence of PD is likely underestimated due to under-reporting bias from those never seeking treatment (Graziottin, 2015