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The authors express concern that there is not yet clear guidance on supplementation route and methods, and they discuss studies exploring this

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PlexusDx supports precision wellness by helping patients and providers evaluate metabolic foundations before starting supplemental protocols, ensuring interventions align with individual physiologic needs rather than general recommendations

[5] Altered sleep patterns, difficulty concentrating, irritability, overactivity, excitability, mental depression, confusion and impaired judgement have all been reported in patients receiving 15 mg of folic acid daily for 1 month