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It appears that between the fourth and tenth month is when the clinical picture is most likely to appear, but there are also cases reported earlier, as well as in older children

Any references to biological activity, molecular pathways, or scientific research are provided solely for educational and informational purposes within the context of laboratory and preclinical research

From a translational perspective, prioritized next steps include well-designed pharmacokinetic and toxicology studies, reproducible efficacy assessments across models, and early-phase clinical trials that emphasize safety and tolerability