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Research suggests that HSCs typically constitute 5%8% of a healthy human liver, primarily regulating ECM synthesis and degradation to modulate hepatic sinusoidal blood supply (El-Serag, 2012)

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4.1.6 Evidence-based prioritization of EV-associated mediators in the IBD-to-CRC transition Although numerous EV-associated inflammatory mediators contribute to the progression from chronic intestinal inflammation to CRC, the robustness of mechanistic and translational evidence differs markedly among mediator classes