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In other systems, canonical Wnt signaling synergizes with TGF signaling to enhance fibrotic responses (262, 263), and this pathway is first activated in LECs at 12 hours PLI and is found in most if not all fibrotic capsule associated cells (CACs) at 5 and 9 days PLI (261)

This overlap is not coincidental but is rooted in shared socioeconomic determinants

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Collagen can also be taken on an empty stomach, though some prefer to mix it into a meal or a smoothie to make it part of a larger nutritional habit