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Alternative approaches to target metabolic dependencies include use of the PPP inhibitor, 6-aminonicotinamide, which demonstrated efficacy in Keap1 fl/fl tumor models [20]

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Therefore, the levels of cytokines (IL-6, IL-12, TNF-) in the macrophage supernatant were detected using an ELISA assay (Fig

The results showed a significant decrease in the symptoms of anxiety and depression [as measured by the Hamilton Depression Rating Scale (HDRS)] and Hamilton Anxiety Rating Scale compared to baseline