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In case of the transporter-mediated prodrug approach, the rational design of prodrugs should take into account the functional expression and structural requirements for substrate binding and translocation via the transporter, as well as capability to be bioconverted by an enzyme at the target site (74)

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The study finds that LGG can be employed to regulate immune homeostasis by regulating the Th1/Th2 ratio, which may reduce overactivated inflammatory reactions involved in autoimmune disorders such as SLE (119)