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4.2.1 NF1-associated OPG displays temporal and spatial specificity and is highly dependent on cell-of-origin and MAPK pathway activation The mTOR pathway had been well-implicated in NF1-associated disorders (85, 95, 96), and it was shown that MAPK pathway activation in NF1 -deficient astrocytes resulted from RAS hyperactivation (78, 85)

Growth hormone has potent lipolytic effects on adipose tissue through direct mechanisms independent of IGF-1

This is due to damage to the gastrointestinal system that limits their B12 absorption and genetic polymorphisms that reduce their B12 utilization

[DOI] [PubMed] [Google Scholar] 87.Colombo G, DalleDonne I, Orioli M, Giustarini D, Rossi R, Clerici M, et al